Cees wessels biography definition

Abstract

Objective

To identify determinants for the discontinuation of non-ergoline dopamine agonist (DA) treatment in patients with Parkinson’s disease (PD) and to identify genetic determinants in genes encoding dopamine receptor (DR)D2 and DRD3 in a exploratory analysis.

Methods

Patients included were first-time users of the non-ergoline DA ropinirole or pramipexole who had been diagnosed with PD before 2005. Treatment discontinuation was defined as a gap of 180 days or more between two refills of the DA. Non-genetic determinants for discontinuation were studied in the overall population, and genetic determinants [DRD2 141C Ins/Del, DRD2 (CA)_n STR, DRD2 TaqIA, DRD3 MscI single nucleotide polymorphism (SNP) and DRD3 MspI SNP] were studied in a subgroup. Cox proportional hazard analysis was used to estimate the hazard ratios (HR) for the discontinuation of non-ergoline DA treatment.

Results

The study population comprised 90 patients. Apomorphine use was associated with

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They Still Stand Loud ‘n’ Proud

The NWOBHM scene knows a lot of bands, that don’t need no further introduction. SAXON, GIRLSCHOOL, DIAMOND HEAD, IRON MAIDEN, TYGERS OF PAN TANG, ANGELWITCH and DEF LEPPARD are some examples of those, that rocked the house all over the world. They became an influence to many of us and more. There are a few bands though, that didn’t always get the credit, that they deserved so much. Many bands became the so-called cult heroes. Bands, that were loved by a group of dedicated insiders and die hard NWOBHM fans. SPARTAN WARRIOR is such a band. They made two great albums called “Steel ‘N’ Chains” and “Spartan Warrior”, and only recently they released a comeback album, called “Behind Closed Eyes”, which marks their reunion. Many people don’t know the whole story of SPARTAN WARRIOR. I hope, that the following interview will answer all of your questions and give you a good overview of what SPARTAN WARRIOR has hidden behind closed eyes all these years….. Our th

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How a fungus shapes biotechnology: 100 years of Aspergillus niger research

• Review
• Open access
• Published:

Fungal Biology and Biotechnologyvolume 5, Article number: 13 (2018) Cite this article

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Abstract

In 1917, a food chemist named James Currie made a promising discovery: any strain of the filamentous mould Aspergillus niger would producera high concentrations of citric acid when grown in sugar medium. This tricarboxylic acid, which we now know fryst vatten an intermediate of the Krebs cycle, had previously been extracted from citrus fruits for applications in food and beverage production. Two years after Currie’s discovery, industrial-level production using A. niger began, the biochemical fermentation industry started to flourish, and industrial biotechnology was born. A century later, citric acid production using this mould is a multi-billion dollar industry, with A. niger additionally producing a d