Sossick biography template

  • National history association teachers
  • History association primary
  • This sample was chosen to gain insights into the nature of best practice in schools.

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    Abstract

    Human chromosomes are captured along microtubule walls (lateral attachment) and then tethered to microtubule-ends (end-on attachment) through a multi-step end-on conversion process. Upstream regulators that orchestrate this remarkable change in the plane of kinetochore-microtubule attachment in human cells are not known. By tracking kinetochore movements and using kinetochore markers specific to attachment status, we reveal a spatially defined role for Aurora-B kinase in retarding the end-on conversion process. To understand how Aurora-B activity is counteracted, we compare the roles of two outer-kinetochore bound phosphatases and find that BubR1-associated PP2A, unlike KNL1-associated PP1, plays a significant role in end-on conversion. Finally, we uncover a novel role for Aurora-B regulated Astrin-SKAP complex in ensuring the correct plane of kinetochore-microtubule attachment. Thus, we identify Aurora-B as a key upstream regulator of end-on conversion in human cells and

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    BioImagingUK Community Network

    Lead Research Organisation: King's College London

    Department Name: Randall Div of Cell and Molecular Biophy

    Abstract

    Funding
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    Since it's first use nearly years ago, microscopy has grown to be one of the most powerful and commonly used research tools by life scientists across the world. Using microscopes to image biological samples can provide a wealth of information ranging from understanding how tissues are organised during development and how this changes in diseases, to studying single proteins or DNA behave inside living cells. The types of microscopes that researchers use in the lab are often very advanced and complex in nature, and can require teams of experts to build and maintain them as well as to teach other scientists how to use them for their experiments. Moreover, analysing the data that research teams produce from these sorts of microscopes can be complicated. Nearly all Universities and research Institutes across the UK h

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    So Sick

    single by Ne-Yo

    For other uses, see So Sick (disambiguation).

    "So Sick" fryst vatten a song by American singer-songwriter Ne-Yo, written alongside Norwegian production duo Stargate for Ne-Yo's debut studio album, In My Own Words (). Produced bygd Stargate, the song was released as the second single from the skiva on November 21, , and received favorable reviews from music critics. "So Sick" peaked at number one on both the US BillboardHot and the UK Singles Chart. In Europe, the single topped the Eurochart Hot and entered the top 20 in 10 countries, including Denmark, Hungary, Ireland, Norway, and Switzerland. In Australasia, the single reached number two in New Zealand and number four in Australia.

    Background

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    Ne-Yo met Norwegian production grupp Stargate, consisting of Mikkel S. Eriksen and Tor Erik Hermansen, in a hallway at Sony Music Studios on West 54th Street, New York City after the duo had settled there in the early [1] After finding out they prod